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GsMTx4
簡(jiǎn)要描述：Smartox Biotechnology是*一家專門生產(chǎn)動(dòng)物毒液多肽毒素，用于細(xì)胞離子通道功能研究的生物醫(yī)藥公司。多肽毒素在生物制藥領(lǐng)域具有重要的使用價(jià)值。
產(chǎn)品型號(hào)：08GSM001- 廠商性質(zhì)：代理商
- 更新時(shí)間：2025-10-25
- 訪 問 量：2381
產(chǎn)品介紹
GsMTx4
Selective blocker of mechanosensitive ion channels
壓力敏感性離子通道選擇性阻斷劑
GsMTx4 (GsMTx-4, M-theraphotoxin-Gr1a) has been isolated from the venom of the spider Grammostola rosea. This cationic hydrophobic polypeptide blocks selectively the gating of cation selective channels and mechanosensitive ion channels such as TRPC1 or TRPC6, without having any effect on whole-cell voltage-sensitive currents. This toxin acts by perturbing the interface between the channel and the lipid bilayer without necessarily being in physical contact with the channel. GsMTx4 also demonstrated to active TRPA1 channel at 1µM concentration and to inhibit Piezo1 currents.
技術(shù)資料
氨基酸序列：
Gly-Cys2-Leu-Glu-Phe-Trp-Trp-Lys-Cys9-Asn-Pro-Asn-Asp-Asp-Lys-Cys16-Cys17-Arg-Pro-Lys-Leu-Lys-Cys23-Ser-Lys-Leu-Phe-Lys-Leu-Cys30-Asn-Phe-Ser-Phe-NH2
二硫鍵：Cys2-Cys17, Cys9-Cys23 and Cys16-Cys30
長(zhǎng)度 (aa)：34
分子式：C185H273N49O45S6
分子量：4095.2 Da
外觀：White lyophilized solid
可溶性：water and saline buffer
CAS 號(hào)：not available
來源： Synthetic
純度： > 97 %
產(chǎn)品信息
08GSM001-00050 | 0.05mg | |
08GSM001-00100 | 0.1mg | |
08GSM001-00500 | 0.5mg |
